Abstract
Background:
Various populations of regulatory cells, including Foxp3+ T(Reg), have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses.
Objective:
In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology*
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Antigen-Presenting Cells / metabolism
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Humans
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Infections / immunology*
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Infections / microbiology
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Infections / virology
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Interleukin-10 / immunology
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Interleukin-10 / metabolism
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Lymphocyte Activation
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism
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Toll-Like Receptors / immunology*
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Toll-Like Receptors / metabolism
Substances
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Toll-Like Receptors
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Interleukin-10