Chemotaxis: TorC before you Akt.

Curr Biol. 2008 Sep 23;18(18):R864-6. doi: 10.1016/j.cub.2008.07.051.

Abstract

Chemotaxis uses intertwined signalling pathways, each individually dispensable. Recent work shows that Dictyostelium PKB/Akt can be spatially regulated independently of phosphatidylinositol (3,4,5)-trisphosphate via phosphorylation by TOR complex 2, placing this complex at the hub of chemotaxis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Chemotaxis / physiology*
  • Dictyostelium / physiology*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / physiology*
  • Transcription Factors / physiology*

Substances

  • Transcription Factors
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt