Abstract
Proviral DNA has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the RNA slow virus visna. A few of these cells also contain the major virion structural antigen p30. This restriction in virus gene expression in the infected animal provides a mechanism for persistence of virus in this chronic infection.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Nucleus / microbiology
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Choroid Plexus / microbiology
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Culture Techniques
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DNA, Viral / analysis*
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RNA Viruses / growth & development*
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Sheep
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Viral Proteins / analysis*
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Virus Replication*
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Visna-maedi virus / analysis
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Visna-maedi virus / growth & development*
Substances
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DNA, Viral
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Viral Proteins