Abstract
Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Chelating Agents / chemical synthesis
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Chelating Agents / chemistry*
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Contrast Media / chemical synthesis
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Contrast Media / chemistry*
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Europium / chemistry
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Image Enhancement / methods*
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Magnetic Resonance Imaging / methods*
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Magnetics*
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Molecular Structure
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Polymers / chemical synthesis
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Polymers / chemistry*
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Sensitivity and Specificity
Substances
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Chelating Agents
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Contrast Media
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Polymers
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Europium