UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation

Leukemia. 2009 Mar;23(3):610-4. doi: 10.1038/leu.2008.249. Epub 2008 Sep 25.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Algorithms
  • Amino Acid Substitution
  • Anemia, Refractory / classification
  • Anemia, Refractory / diagnosis
  • Anemia, Refractory / genetics*
  • Chromosomes, Human, Pair 1 / genetics*
  • Humans
  • Janus Kinase 2 / genetics
  • Loss of Heterozygosity / genetics*
  • Middle Aged
  • Mutation, Missense
  • Phenotype
  • Phosphorylation
  • Point Mutation
  • Polymorphism, Single Nucleotide
  • Protein Processing, Post-Translational
  • Receptors, Thrombopoietin / genetics*
  • STAT5 Transcription Factor / metabolism
  • Thrombocytosis / diagnosis
  • Thrombocytosis / genetics*
  • Uniparental Disomy / genetics*

Substances

  • Receptors, Thrombopoietin
  • STAT5 Transcription Factor
  • MPL protein, human
  • JAK2 protein, human
  • Janus Kinase 2