Successful treatment of adrenocortical carcinoma with pulmonary metastasis in a child: report of a case

Surg Today. 2008;38(10):965-9. doi: 10.1007/s00595-008-3788-5. Epub 2008 Sep 27.

Abstract

Adrenocortical carcinoma (ACC) in childhood is rare: in 2002, only three new cases were reported in Japan. Although there is no established therapeutic management system, margin-free complete surgical excision of the tumor is very important to a satisfactory outcome. We report a case of ACC with bilateral pulmonary metastasis in a 10-year-old boy. Preoperative chest computed tomography (CT) showed pulmonary metastasis with near-water density. The patient was treated successfully with complete surgical resection of the primary tumor and adjuvant chemotherapy, including mitotane. After bilateral lung surgery for the metastatic lesions, the plasma dehydroepiandrosterone sulfate level became negative.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Neoplasms / pathology*
  • Adrenocortical Carcinoma / diagnostic imaging
  • Adrenocortical Carcinoma / drug therapy
  • Adrenocortical Carcinoma / secondary*
  • Adrenocortical Carcinoma / surgery
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Chemotherapy, Adjuvant
  • Child
  • Combined Modality Therapy
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / secondary*
  • Lung Neoplasms / surgery
  • Male
  • Mitotane / therapeutic use
  • Tomography, X-Ray Computed

Substances

  • Antineoplastic Agents, Hormonal
  • Mitotane