Abstract
we found that 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives 8d, 8e and 8f could effectively induce apoptosis in A549 lung cancer cells and elevate the levels of integrin beta4 and ROS. The data suggested that these compounds might be promising agents for the cancer therapy, and these compounds would be useful tools for further investigate the functions of integrin beta4 in regulation of the cancer cell apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Ferrous Compounds / chemistry*
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Ferrous Compounds / pharmacology*
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Humans
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Integrin beta4 / genetics
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Integrin beta4 / metabolism
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Lung Neoplasms / genetics
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Lung Neoplasms / metabolism
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Lung Neoplasms / pathology*
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Molecular Structure
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Pyrazines / chemistry*
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Pyrazines / pharmacology*
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Pyrazoles / chemistry*
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Pyrazoles / pharmacology*
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RNA, Small Interfering / genetics
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Reactive Oxygen Species / metabolism
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Structure-Activity Relationship
Substances
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Ferrous Compounds
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Integrin beta4
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Pyrazines
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Pyrazoles
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RNA, Small Interfering
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Reactive Oxygen Species