Colon cancer: it's CIN or CIMP

Clin Cancer Res. 2008 Oct 1;14(19):5939-40. doi: 10.1158/1078-0432.CCR-08-1596.

Abstract

Combined genetic and epigenetic analysis of sporadic colon cancer suggest that it can no longer be viewed as a single disease. There are at least three different subsets with distinct clinico-pathologic features, with important implications for preventions, screening, and therapy.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomal Instability*
  • Colonic Neoplasms / diagnosis*
  • Colonic Neoplasms / genetics*
  • CpG Islands
  • DNA Methylation*
  • Disease Progression
  • Epigenesis, Genetic
  • Humans
  • Loss of Heterozygosity
  • Methylation
  • Microsatellite Repeats
  • Models, Biological
  • Models, Genetic
  • Neoplasm Metastasis
  • Phenotype
  • Prognosis