Abstract
Combined genetic and epigenetic analysis of sporadic colon cancer suggest that it can no longer be viewed as a single disease. There are at least three different subsets with distinct clinico-pathologic features, with important implications for preventions, screening, and therapy.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromosomal Instability*
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Colonic Neoplasms / diagnosis*
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Colonic Neoplasms / genetics*
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CpG Islands
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DNA Methylation*
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Disease Progression
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Epigenesis, Genetic
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Humans
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Loss of Heterozygosity
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Methylation
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Microsatellite Repeats
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Models, Biological
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Models, Genetic
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Neoplasm Metastasis
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Phenotype
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Prognosis