Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir

Clin Infect Dis. 2008 Nov 1;47(9):1222-5. doi: 10.1086/592304.

Abstract

This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T-->C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Atazanavir Sulfate
  • Cohort Studies
  • Female
  • HIV Infections / blood
  • HIV Infections / drug therapy
  • HIV Infections / genetics
  • HIV Protease Inhibitors / administration & dosage
  • HIV Protease Inhibitors / blood
  • HIV Protease Inhibitors / pharmacokinetics*
  • Humans
  • Male
  • Middle Aged
  • Oligopeptides / administration & dosage
  • Oligopeptides / blood
  • Oligopeptides / pharmacokinetics*
  • Polymorphism, Single Nucleotide*
  • Pregnane X Receptor
  • Pyridines / administration & dosage
  • Pyridines / blood
  • Pyridines / pharmacokinetics*
  • Receptors, Steroid / genetics*
  • Receptors, Steroid / metabolism

Substances

  • HIV Protease Inhibitors
  • Oligopeptides
  • Pregnane X Receptor
  • Pyridines
  • Receptors, Steroid
  • Atazanavir Sulfate