Abstract
Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains. The 7-valent pneumococcal conjugate vaccine (PCV) showed better coverage of PRSP strains (87.0%). The 7-valent PCV may reduce the prevalence of PRSP in Japan.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Child
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Child, Preschool
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Ear, Middle / microbiology*
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Exudates and Transudates / microbiology*
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Heptavalent Pneumococcal Conjugate Vaccine
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Humans
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Infant
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Japan / epidemiology
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Otitis Media / microbiology*
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Penicillin Resistance*
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Penicillins / pharmacology
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Pneumococcal Infections / epidemiology
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Pneumococcal Infections / microbiology*
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Pneumococcal Vaccines / immunology
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Serotyping
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Streptococcus pneumoniae / classification*
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / isolation & purification
Substances
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Anti-Bacterial Agents
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Heptavalent Pneumococcal Conjugate Vaccine
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Penicillins
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Pneumococcal Vaccines