Analyzing center specific outcomes in hematopoietic cell transplantation

Lifetime Data Anal. 2008 Dec;14(4):389-404. doi: 10.1007/s10985-008-9100-6. Epub 2008 Oct 3.

Abstract

Reporting transplant center-specific survival rates after hematopoietic cell transplantation is required in the United States. We describe a method to report 1-year survival outcomes by center, as well as to quantify center performance relative to the transplant center network average, which can be reliably used with censored data and for small center sizes. Each center's observed 1-year survival outcome is compared to a predicted survival outcome adjusted for patient characteristics using a pseudovalue regression technique. A 95% prediction interval for 1-year survival assuming no center effect is computed for each center by bootstrapping the scaled residuals from the regression model, and the observed 1-year survival is compared to this prediction interval to determine center performance. We illustrate the technique using a recent center specific analysis performed by the Center for International Blood and Marrow Transplant Research, and study the performance of this method using simulation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Computer Simulation
  • Data Interpretation, Statistical
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hematopoietic Stem Cell Transplantation / mortality*
  • Humans
  • Outcome Assessment, Health Care / methods*
  • Regression Analysis
  • Risk Factors
  • Sensitivity and Specificity
  • Survival Analysis
  • Treatment Outcome
  • United States