Primary signet ring cell carcinoma of the appendix: a rare case report and our 18-year experience

World J Gastroenterol. 2008 Oct 7;14(37):5763-8. doi: 10.3748/wjg.14.5763.

Abstract

Primary adenocarcinoma of the appendix is a rare malignancy that constitutes < 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carcinoma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appendectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent appendectomy and bilateral salpingo-oophorectomy with a laparoscopy procedure. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-flurorouracil, and leucovorin (FOLFOX-4). The patient currently is well without progression of disease 12 mo after beginning chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Appendectomy
  • Appendiceal Neoplasms / pathology*
  • Appendiceal Neoplasms / therapy
  • Carcinoma, Signet Ring Cell / secondary*
  • Carcinoma, Signet Ring Cell / therapy
  • Chemotherapy, Adjuvant
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ovarian Neoplasms / secondary*
  • Ovarian Neoplasms / therapy
  • Ovariectomy
  • Peritoneal Neoplasms / secondary*
  • Peritoneal Neoplasms / therapy
  • Tomography, X-Ray Computed
  • Treatment Outcome