Abstract
Background:
Serotonin 1A receptors (5-HT(1A)) have not been studied in dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) patients with depression.
Aim:
To examine 5-HT(1A) in DLB and PDD postmortem in relation to depression.
Methods:
[(3)H]8-hydroxy-2-dipropylaminotetralin binding to 5-HT(1A) was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls.
Results:
5-HT(1A) density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20.
Conclusion:
Higher BA36 5-HT(1A) density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT(1A) antagonist adjuvant may improve treatment of depression in dementia.
Copyright 2008 S. Karger AG, Basel.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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8-Hydroxy-2-(di-n-propylamino)tetralin / metabolism
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8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacokinetics
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Aged
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Aged, 80 and over
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Antidepressive Agents / therapeutic use
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Antiparkinson Agents / therapeutic use
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Autopsy
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Cerebral Cortex / metabolism*
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Dementia / complications
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Dementia / metabolism*
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Dementia / psychology*
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Depression / etiology
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Depression / metabolism*
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Depression / psychology*
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Female
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Humans
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Levodopa / therapeutic use
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Lewy Body Disease / complications
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Lewy Body Disease / metabolism*
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Lewy Body Disease / psychology*
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Male
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Middle Aged
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Parkinson Disease / complications*
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Parkinson Disease / psychology*
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Receptor, Serotonin, 5-HT1A / metabolism*
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Serotonin Receptor Agonists / metabolism
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Serotonin Receptor Agonists / pharmacokinetics
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Temporal Lobe / metabolism
Substances
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Antidepressive Agents
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Antiparkinson Agents
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Serotonin Receptor Agonists
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Receptor, Serotonin, 5-HT1A
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Levodopa
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8-Hydroxy-2-(di-n-propylamino)tetralin