Nonrandom t(1;22)(p12-p13;q13) in acute megakaryocytic malignant proliferation

A Baruchel; M T Daniel; G Schaison; R Berger

doi:10.1016/0165-4608(91)90213-e

Nonrandom t(1;22)(p12-p13;q13) in acute megakaryocytic malignant proliferation

Cancer Genet Cytogenet. 1991 Jul 15;54(2):239-43. doi: 10.1016/0165-4608(91)90213-e.

Authors

A Baruchel¹, M T Daniel, G Schaison, R Berger

Affiliation

¹ Service D'Hématologie Pédiatrique, Hôpital Saint-Louis, Paris, France.

PMID: 1884357
DOI: 10.1016/0165-4608(91)90213-e

Abstract

A case of acute megakaryocytic leukemia (M7) and one of acute myeloid hemopathy affecting megakaryocytic and erythrocytic cell lineages in infants are reported. Both patients had t(1;22)(p12-p13;q13). This translocation was previously observed in a congenital M7 leukemia. These studies suggest that t(1;22) translocation can be nonrandom in M7.

Publication types

Case Reports

MeSH terms

Chromosome Banding
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 22*
Female
Humans
Infant
Leukemia, Megakaryoblastic, Acute / genetics*
Male
Translocation, Genetic