The idiopathic interstitial pneumonias are a heterogeneous group of diseases that have similar clinical symptoms. The new classification is based mainly on differences in histologic patterns, however high-resolution computed tomography is a significant tool that helps in making a firm diagnosis. Desquamative interstitial pneumonia is relatively rare form idiopathic interstitial pneumonia. It affects mainly men in their fourth or fifth decade of life who have a history of smoking. We report a case of 50-years-old man admitted to hospital for further diagnosis of prolonged bilateral pneumonia. His main complaints were fatigue, productive cough and subfebrile body temperature. Having performed additional diagnostic procedures including videothoracoscopy, what was in accordance with contemporary guidelines, we achieved a final diagnosis of desquamative interstitial pneumonia. Treatment with systemic corticosteroids resulted in disease remission.