Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-alpha treatment in a suspected case of hyper-IgE syndrome

Pediatr Allergy Immunol. 2008 Sep;19(6):564-8. doi: 10.1111/j.1399-3038.2007.00683.x.

Abstract

We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-alpha (IFN-alpha) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-alpha as immunomodulating drug.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Cytokines / analysis*
  • Cytokines / immunology
  • Eczema / drug therapy*
  • Eczema / immunology
  • Eosinophilia / immunology
  • Humans
  • Immunoglobulin E / blood*
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use*
  • Job Syndrome / drug therapy*
  • Job Syndrome / immunology
  • Male
  • Recombinant Proteins
  • Th1 Cells / immunology
  • Th1 Cells / metabolism
  • Th2 Cells / immunology
  • Th2 Cells / metabolism

Substances

  • Cytokines
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Immunoglobulin E