Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects

Curr Opin Pharmacol. 2008 Dec;8(6):765-76. doi: 10.1016/j.coph.2008.09.005. Epub 2008 Oct 24.

Abstract

Annexin A1 (ANXA1, formerly termed lipocortin 1 or macrocortin) is an important protein mediator of the feedback actions of glucocorticoids within the hypothalamo-pituitary-adrenocortical (HPA) axis. Here we consider the mechanisms by which ANXA1 exerts these actions, with particular reference to the potential role of the formyl peptide receptors (FPRs), a family of G-protein-coupled receptors which has only very recently been implicated in the regulation of neuroendocrine function. In addition, we discuss evidence that ANXA1 contributes to the regulation of other aspects of endocrine and metabolic function and to the aetiology of sexual dimorphisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Annexin A1 / metabolism
  • Annexin A1 / physiology*
  • Glucocorticoids / metabolism
  • Glucocorticoids / physiology
  • Humans
  • Hypothalamo-Hypophyseal System / physiology*
  • Models, Biological
  • Pituitary-Adrenal System / physiology*
  • Receptors, Formyl Peptide / metabolism
  • Receptors, Formyl Peptide / physiology*
  • Signal Transduction / physiology

Substances

  • Annexin A1
  • Glucocorticoids
  • Receptors, Formyl Peptide