Millisecond-scale differences in neural activity in auditory cortex can drive decisions

Nat Neurosci. 2008 Nov;11(11):1262-3. doi: 10.1038/nn.2211. Epub 2008 Oct 12.

Abstract

Neurons in the auditory cortex can lock to the fine timing of acoustic stimuli with millisecond precision, but it is not known whether this precise spike timing can be used to guide decisions. We used chronically implanted microelectrode pairs to stimulate neurons in the rat auditory cortex directly and found that rats can exploit differences in the timing of cortical activity that are as short as 3 ms to guide decisions.

MeSH terms

  • Acoustic Stimulation / methods
  • Animals
  • Auditory Cortex / cytology*
  • Auditory Perception / physiology*
  • Male
  • Neurons / physiology*
  • Probability
  • Rats
  • Rats, Long-Evans
  • Time Factors
  • Time Perception / physiology*
  • Water Deprivation / physiology