Abstract
Memories are dynamic, rather than static, in nature. The reactivation of a memory through re-exposure to salient training stimuli results in its destabilization, necessitating a restabilization process known as reconsolidation, a disruption of which leads to amnesia. I found that one normal function of hippocampal memory reconsolidation in rats is to modify the strength of a contextual-fear memory as a result of further learning.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amnesia / chemically induced
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Amnesia / physiopathology
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Analysis of Variance
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Animals
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Anisomycin / pharmacology
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Behavior, Animal / drug effects
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Brain-Derived Neurotrophic Factor / chemistry
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Conditioning, Psychological / drug effects
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Early Growth Response Protein 1 / chemistry
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Fear / drug effects
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Freezing Reaction, Cataleptic / drug effects
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Hippocampus / drug effects
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Lactones / pharmacology
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Learning / drug effects
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Learning / physiology*
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Male
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Memory / drug effects
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Memory / physiology*
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Oligodeoxyribonucleotides, Antisense / pharmacology
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Protein Synthesis Inhibitors / pharmacology
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Rats
Substances
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Brain-Derived Neurotrophic Factor
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Early Growth Response Protein 1
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Egr1 protein, rat
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Lactones
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Oligodeoxyribonucleotides, Antisense
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Protein Synthesis Inhibitors
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clasto-lactacystin beta-lactone
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Anisomycin