Characterization of pUO-StVR2, a virulence-resistance plasmid evolved from the pSLT virulence plasmid of Salmonella enterica serovar Typhimurium

Antimicrob Agents Chemother. 2008 Dec;52(12):4514-7. doi: 10.1128/AAC.00563-08. Epub 2008 Oct 13.

Abstract

pUO-StVR2 is a virulence-resistance plasmid which originated from pSLT of Salmonella enterica serovar Typhimurium through acquisition of a complex resistance island, flanked by regions that provide a toxin-antitoxin system and an iron uptake system. The presence of resistance and virulence determinants on the same plasmid allows coselection of both properties, potentially increasing health risks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • DNA Transposable Elements
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial / genetics*
  • Evolution, Molecular*
  • Humans
  • Molecular Sequence Data
  • Plasmids / genetics*
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / pathogenicity*
  • Sequence Analysis, DNA
  • Virulence / genetics

Substances

  • Bacterial Proteins
  • DNA Transposable Elements
  • DNA, Bacterial

Associated data

  • GENBANK/AM991977