Abstract
CTCF plays diverse roles in the regulation of eukaryotic genes. A new study by Lefevre et al. in a recent issue of Molecular Cell reveals a novel mechanism in which noncoding RNA transcription and nucleosome repositioning evicts CTCF from a regulatory element to facilitate induction of a nearby gene.
MeSH terms
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CCCTC-Binding Factor
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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DNA-Binding Proteins / physiology*
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Humans
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Insulator Elements / genetics*
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Models, Biological
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Nucleosomes
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RNA, Untranslated / genetics*
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RNA, Untranslated / physiology
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
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Repressor Proteins / physiology*
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Transcription, Genetic
Substances
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CCCTC-Binding Factor
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CTCF protein, human
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DNA-Binding Proteins
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Nucleosomes
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RNA, Untranslated
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Repressor Proteins