Repeated high doses of clopidogrel in 2 cases of pharmacological resistance

Guillaume Cayla; Jean Christophe Macia; François Roubille; Herisoa Rabesendratana; Christophe Piot; Jean François Schved; Florence Leclercq

doi:10.1253/circj.cj-07-1018

Repeated high doses of clopidogrel in 2 cases of pharmacological resistance

Circ J. 2008 Dec;72(12):2098-100. doi: 10.1253/circj.cj-07-1018. Epub 2008 Oct 14.

Authors

Guillaume Cayla¹, Jean Christophe Macia, François Roubille, Herisoa Rabesendratana, Christophe Piot, Jean François Schved, Florence Leclercq

Affiliation

¹ Department of Cardiology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Universitaire, Montpellier, France. [email protected]

PMID: 18854615
DOI: 10.1253/circj.cj-07-1018

Abstract

In the case of stent thrombosis and resistance to clopidogrel, choices of an alternative drug remain limited. In 2 cases of subacute stent thrombosis associated with clopidogrel resistance, an adequate response was obtained in these patients after repeated loading doses of clopidogrel.

Publication types

Case Reports

MeSH terms

Acute Coronary Syndrome / therapy*
Angioplasty, Balloon, Coronary / adverse effects*
Blood Platelets / drug effects*
Blood Platelets / metabolism
Cell Adhesion Molecules / blood
Clopidogrel
Drug Administration Schedule
Drug Resistance*
Humans
Male
Microfilament Proteins / blood
Middle Aged
Phosphoproteins / blood
Phosphorylation
Platelet Aggregation Inhibitors / administration & dosage*
Platelet Aggregation Inhibitors / adverse effects
Platelet Function Tests
Thrombosis / etiology
Thrombosis / prevention & control*
Ticlopidine / administration & dosage
Ticlopidine / adverse effects
Ticlopidine / analogs & derivatives*
Treatment Failure
Vasodilator-Stimulated Phosphoprotein

Substances

Cell Adhesion Molecules
Microfilament Proteins
Phosphoproteins
Platelet Aggregation Inhibitors
Vasodilator-Stimulated Phosphoprotein
Clopidogrel
Ticlopidine