Abstract
The beneficial properties of fish oil are well known and are related to its fatty acid composition rich in omega-3 polyunsaturated fatty acids. In the last years a variety of epidemiological and clinical studies have demonstrated the efficacy of fish oil supplementation in the rheumatic diseases, in particular in rheumatoid arthritis. The anti-inflammatory effects of fish oil are linked to the production of alternative eicosanoids, to the reduction of proinflammatory cytokines, to the inhibition of the activation of T lymphocytes and of catabolic enzymes. Fish oil supplementation could represent a valuable support to the traditional pharmacological treatment of rheumatoid arthritis.
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / economics
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Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Arthritis, Rheumatoid / drug therapy*
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Clinical Trials as Topic
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Cyclosporine / pharmacokinetics
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Dietary Supplements*
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Drug Costs
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Drug Interactions
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Eicosapentaenoic Acid / pharmacology
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Eicosapentaenoic Acid / therapeutic use
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Fatty Acids, Unsaturated / pharmacology
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Fatty Acids, Unsaturated / therapeutic use
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Fish Oils / economics
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Fish Oils / pharmacokinetics
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Fish Oils / pharmacology
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Fish Oils / therapeutic use*
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Humans
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Methotrexate / pharmacokinetics
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Sulfasalazine / pharmacokinetics
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Fatty Acids, Unsaturated
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Fish Oils
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Sulfasalazine
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Cyclosporine
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Eicosapentaenoic Acid
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docosapentaenoic acid
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Methotrexate