Detection of Helicobacter pylori carriers by discriminant analysis of urea and pH levels in gastric juices

J Clin Pathol. 1991 Aug;44(8):697-8. doi: 10.1136/jcp.44.8.697.

Abstract

An alternative approach to the problems inherent in current methods for detecting Helicobacter pylori carriers--that of being generally time-consuming, expensive, and not sufficiently sensitive--was devised by using the urea concentration and pH levels of gastric juices. A linear discriminant analysis of these variables, measured in 54 patients submitted to digestive endoscopy for gastritis, provided a mathematical formula for assigning the subjects (previously classified by other standard methods) to groups of either positive or negative H pylori carriers. The results obtained showed a correct classification in 52 out of 54 cases with only one false negative and one false positive case.

MeSH terms

  • Adult
  • Carrier State / diagnosis*
  • Carrier State / metabolism
  • Discriminant Analysis
  • Female
  • Gastric Juice / chemistry*
  • Helicobacter Infections / diagnosis*
  • Helicobacter Infections / metabolism
  • Helicobacter pylori*
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Middle Aged
  • Urea / analysis*

Substances

  • Urea