[Estimation of GFR from serum creatinine and cystatin C-A comparison of 2 methods in patients with neurogenic bladder due to myelomeningocle (MMC)]

Pol Merkur Lekarski. 2008:24 Suppl 4:119-20.
[Article in Polish]

Abstract

Glomerular filtration rate (eGFR) calculated from serum creatinine can be overestimated in patients with muscle mass deficits.

Aim: The aim of this study was to compare eGFR calculated from serum levels of creatinine and cystatin C in a group of patients with neurogenic bladder due to MMC.

Material and methods: GFR calculations were performed for 67 patients using Schwartz formula for creatinine measured by colorimetric method and Filler formula for cystatin C measured by immunonephelometric method.

Results: Statistically significant lower eGFR values were obtained with calculations based on cystatin C levels.

Conclusion: Cystatin C is a useful marker for GFR estimations in patients with reduced muscle mass.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Creatinine / blood*
  • Cystatin C
  • Cystatins / blood*
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Kidney Function Tests / methods*
  • Male
  • Meningomyelocele / complications*
  • Urinary Bladder, Neurogenic / blood
  • Urinary Bladder, Neurogenic / etiology
  • Urinary Bladder, Neurogenic / physiopathology*

Substances

  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • Creatinine