Bite force and pattern measurements for dental pain assessment in the rat

Neurosci Lett. 2008 Dec 12;447(2-3):175-8. doi: 10.1016/j.neulet.2008.10.008. Epub 2008 Oct 7.

Abstract

We present simple method to assess dental pain in the awake rat. Using a sensitive strain gauge we examined changes in bite strength and bite pattern in rats following dental injury. Rats with dental injury displayed a significant reduction in mean peak bite strength and an altered bite cluster pattern. Both changes in the dental injury rats were reversed by an analgesic dose of morphine, and this could be reversed with naloxone. These changes were not observed in naive control animals. This simple method significantly improves our ability to evaluate dental pain syndromes.

MeSH terms

  • Analgesics, Opioid / pharmacology
  • Analysis of Variance
  • Animals
  • Bite Force*
  • Dental Pulp / drug effects
  • Dental Pulp / physiology
  • Dental Stress Analysis
  • Male
  • Morphine / pharmacology
  • Naloxone / pharmacology
  • Narcotic Antagonists / pharmacology
  • Pain / diagnosis
  • Pain / physiopathology*
  • Pain Measurement / instrumentation
  • Pain Measurement / methods*
  • Random Allocation
  • Rats
  • Rats, Long-Evans
  • Time Factors

Substances

  • Analgesics, Opioid
  • Narcotic Antagonists
  • Naloxone
  • Morphine