Dimethyl sulfoxide perfusion in caprine ovarian tissue and its relationship with follicular viability after cryopreservation

Fertil Steril. 2009 Apr;91(4 Suppl):1513-5. doi: 10.1016/j.fertnstert.2008.07.1778. Epub 2008 Oct 18.

Abstract

Ovarian cortical fragments (3 x 3 x 1 mm) were exposed to dimethyl sulfoxide (DMSO) in different concentrations for further analysis of cryoprotectant perfusion by applying high-performance liquid chromatography (HPLC) and conventional cryopreservation. This simple perfusion test can predict the efficiency of the cryopreservation procedure.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid / methods*
  • Cryopreservation / methods*
  • Cryoprotective Agents / administration & dosage
  • Cryoprotective Agents / pharmacology*
  • Dimethyl Sulfoxide / administration & dosage
  • Dimethyl Sulfoxide / pharmacology*
  • Dose-Response Relationship, Drug
  • Female
  • Goats
  • Models, Animal
  • Ovarian Follicle / drug effects*
  • Ovarian Follicle / physiology
  • Ovary / drug effects*
  • Ovary / physiology
  • Perfusion / methods
  • Tissue Survival / drug effects*
  • Tissue Survival / physiology

Substances

  • Cryoprotective Agents
  • Dimethyl Sulfoxide