Abstract
An assay of neutralizing activity against CHO cell-clustering activity, one of the most common assays for anti-pertussis toxin antibodies, did not correlate well with an assay of the protective activities of monoclonal antibodies. A better correlation between neutralization of leukocytosis-promoting or islet-activating activity and mouse protection against aerosol challenge was seen.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Diphosphate Ribose / metabolism
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Animals
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Antibodies, Monoclonal / immunology*
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Cricetinae
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Leukocytosis / chemically induced
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Mice
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Pertussis Toxin*
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Virulence Factors, Bordetella / immunology*
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Virulence Factors, Bordetella / toxicity
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Whooping Cough / prevention & control*
Substances
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Antibodies, Monoclonal
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Virulence Factors, Bordetella
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Adenosine Diphosphate Ribose
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Pertussis Toxin