Abstract
Thirteen extensively drug-resistant tuberculosis isolates which were highly resistant to a broad spectrum of antituberculosis drugs were identified from 1,926 clinical isolates in China. They had highly diverse mycobacterial interspersed repetitive-unit-variable-number tandem-repeat patterns. Most, but not all, of the drug target genes had mutations contributing to resistance to the corresponding drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antitubercular Agents / pharmacology
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China
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DNA Fingerprinting
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DNA, Bacterial / genetics
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Drug Resistance, Multiple, Bacterial
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Extensively Drug-Resistant Tuberculosis / microbiology*
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Female
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Genes, Bacterial
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Genotype
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Humans
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Male
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Middle Aged
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Minisatellite Repeats / genetics*
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Mutation, Missense
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Mycobacterium tuberculosis / classification*
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / isolation & purification*
Substances
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Antitubercular Agents
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DNA, Bacterial