Abstract
MicroRNA (miRNA) expression is tissue specific or cell-type specific. miRNA signatures are useful tools for tumor classification and target gene identification. We and others found that uterine leiomyomas (ULMs) expressed a distinct miRNA signature. In addition, miRNA expression appears to be strongly associated with race and other biomedical factors, such as tumor sizes. Among the most highly dysregulated miRNAs, let-7 miRNAs seem to play a critical role in tumorigenesis of ULMs through negative regulation of some key target oncogenes, including high mobility group 2.
MeSH terms
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Biomedical Research / methods
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Biomedical Research / trends
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Drug Discovery / methods
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Drug Discovery / trends*
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Ethnicity / genetics
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Female
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic
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Humans
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Leiomyoma / diagnosis*
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Leiomyoma / ethnology
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Leiomyoma / genetics
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Leiomyoma / therapy*
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MicroRNAs / genetics
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MicroRNAs / physiology*
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Oligonucleotide Array Sequence Analysis
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Prognosis
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Risk Assessment / methods
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Risk Assessment / trends
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Uterine Neoplasms / diagnosis*
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Uterine Neoplasms / ethnology
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Uterine Neoplasms / genetics
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Uterine Neoplasms / therapy*