Abstract
Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects. Current results suggest that the mu-opioid agonist, loperamide, has a potential analgesic effect that could be clinically used as a peripheral analgesic agent for stomatitis pain. However, these observations will need to be further confirmed in a randomized-controlled trial.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Analgesics / administration & dosage
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Analgesics / pharmacology
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Analgesics / therapeutic use*
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Bone Marrow Transplantation
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Chronic Disease
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Female
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Graft vs Host Disease / complications*
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Humans
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Loperamide / administration & dosage
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Loperamide / pharmacology
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Loperamide / therapeutic use*
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Male
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Middle Aged
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Mouthwashes
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Pain / drug therapy*
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Pain / etiology*
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Quality of Life
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Receptors, Opioid, mu / agonists*
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Stomatitis / complications*
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Stomatitis / etiology
Substances
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Analgesics
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Mouthwashes
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Receptors, Opioid, mu
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Loperamide