Cytotoxic constituents ofPilea mongolica

H C Kwon; K R Lee; O P Zee

doi:10.1007/BF02974007

Cytotoxic constituents ofPilea mongolica

Arch Pharm Res. 1997 Apr;20(2):180-3. doi: 10.1007/BF02974007.

Authors

H C Kwon¹, K R Lee, O P Zee

Affiliation

¹ Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University, 440-746, Suwon, Kyunggi-Do, Korea.

PMID: 18975198
DOI: 10.1007/BF02974007

Abstract

Bioassay-guided fractionation of the aerial parts ofPilea mongolica (Urticaceae) afforded two cytotoxic triterpenoids, epi-oleanolic acid (I) and oxo-oleanolic acid (II). The structures of the compounds were confirmed by spectral and synthetic evidences. CompoundI and compoundII exhibited cytotoxicity against cultured human tumor cell lines, A549 (non small cell lung adenocarcinoma), SK-OV-3 (ovarian), SK-MEL-2 (skin melanoma), XF498 (CNS) and HCT15 (colon) with ED(50) values of 3.2 approximately 8.1 mug/ml and 0.7 approximately 6.8 mug/ml, respectively.