Gypsy endogenous retrovirus maintains potential infectivity in several species of Drosophilids

BMC Evol Biol. 2008 Oct 31:8:302. doi: 10.1186/1471-2148-8-302.

Abstract

Background: Sequences homologous to the gypsy retroelement from Drosophila melanogaster are widely distributed among drosophilids. The structure of gypsy includes an open reading frame resembling the retroviral gene env, which is responsible for the infectious properties of retroviruses.

Results: In this study we report molecular and phylogeny analysis of the complete env gene from ten species of the obscura group of the genus Drosophila and one species from the genus Scaptomyza.

Conclusion: The results indicate that in most cases env sequences could produce a functional Env protein and therefore maintain the infectious capability of gypsy in these species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cloning, Molecular
  • DNA / genetics
  • Drosophilidae / genetics*
  • Drosophilidae / virology
  • Endogenous Retroviruses / genetics*
  • Evolution, Molecular*
  • Genes, Insect
  • Genes, env*
  • Genome, Insect
  • Likelihood Functions
  • Models, Genetic
  • Open Reading Frames
  • Phylogeny
  • Protein Biosynthesis
  • RNA, Messenger / genetics
  • Retroelements*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Viral Envelope Proteins / genetics

Substances

  • RNA, Messenger
  • Retroelements
  • Viral Envelope Proteins
  • DNA