Regulation of synaptic connectivity with chronic cocaine

Am J Psychiatry. 2008 Nov;165(11):1393. doi: 10.1176/appi.ajp.2008.08101465.
No abstract available

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / physiopathology
  • Cocaine / toxicity*
  • Cocaine-Related Disorders / physiopathology*
  • Cocaine-Related Disorders / rehabilitation
  • Corpus Striatum / drug effects
  • Corpus Striatum / physiopathology
  • Cyclic AMP / metabolism
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Dendritic Spines / drug effects*
  • Dendritic Spines / physiology
  • Disease Models, Animal
  • Gene Expression / drug effects
  • Humans
  • MEF2 Transcription Factors
  • Myogenic Regulatory Factors / genetics
  • Neuronal Plasticity / drug effects
  • Neuronal Plasticity / physiology
  • Nucleus Accumbens / drug effects
  • Nucleus Accumbens / physiopathology
  • Receptors, Dopamine D1 / drug effects
  • Receptors, Dopamine D1 / physiology
  • Receptors, Dopamine D5 / drug effects
  • Receptors, Dopamine D5 / physiology
  • Reward
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Synaptic Transmission / drug effects*
  • Synaptic Transmission / physiology

Substances

  • MEF2 Transcription Factors
  • Myogenic Regulatory Factors
  • Receptors, Dopamine D1
  • Receptors, Dopamine D5
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases
  • Cocaine