[Demonstration of leukemic stem cells in the human T-ALLs and study of the involvement of the NOTCH, TAL1 and ERK/MAPK pathways in human T-leukemogenesis]

Ann Pathol. 2008 Nov;28 Spec No 1(1):S28-9. doi: 10.1016/j.annpat.2008.09.004. Epub 2008 Oct 17.

[Article in French]

Authors

Bastien Gerby¹, Florence Armstrong, Philippe Brunet de la Grange, Julien Calvo, Paula Ballerini, Françoise Pflumio

Affiliation

¹ Laboratoire des cellules souches hématopoïétiques et leucémiques, institut de radiobiologie moléculaire et cellulaire, CEA, 18, route de Panorama, BP 6, 92265 Fontenay-aux-Roses, France.

PMID: 18984291
DOI: 10.1016/j.annpat.2008.09.004

No abstract available

MeSH terms

Basic Helix-Loop-Helix Transcription Factors / physiology*
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism
Cell Transformation, Neoplastic / pathology*
Extracellular Signal-Regulated MAP Kinases / physiology*
Humans
MAP Kinase Signaling System
Neoplasm Proteins / physiology*
Neoplastic Stem Cells / pathology*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
Proto-Oncogene Proteins / physiology*
Receptors, Notch / physiology*
Signal Transduction*
T-Cell Acute Lymphocytic Leukemia Protein 1

Substances

Basic Helix-Loop-Helix Transcription Factors
Neoplasm Proteins
Proto-Oncogene Proteins
Receptors, Notch
T-Cell Acute Lymphocytic Leukemia Protein 1
TAL1 protein, human
Extracellular Signal-Regulated MAP Kinases