Abstract
A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper(I) catalysed 'click' chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of the ligands; the optimal ligands demonstrate a high degree of selective telomeric G-quadruplex stabilisation and are not cytotoxic in several cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding Sites
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Catalysis
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Cattle
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Copper / chemistry
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DNA / drug effects
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Drug Screening Assays, Antitumor
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Fluorescence Resonance Energy Transfer
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G-Quadruplexes*
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Humans
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Ligands
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Models, Molecular
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Molecular Structure
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Triazoles / chemistry*
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Urea / analogs & derivatives*
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Urea / chemistry*
Substances
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Ligands
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Triazoles
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Copper
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Urea
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DNA