Abstract
Retroperitoneal fibrosis is characterized by the presence of a retroperitoneal tissue, consisting of chronic inflammation and marked fibrosis, which entraps the retroperitoneal organs. In two-thirds of cases, the retroperitoneal fibrosis is idiopathic. The pathogenic mechanism is not clearly identified. We report a case of idiopathic retroperitoneal fibrosis associated with type 1 diabetes mellitus. A 61-year-old woman with C peptide negative insulindependent diabetes developed retroperitoneal fibrosis revealed by bilateral hydronephrosis. Anti-GAD 65 antibodies were positive. There were no signs of autoimmune pancreatitis: no steatorrhea, normal IgG4 isotype levels, and absence of pancreas morphological abnormalities.
MeSH terms
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Anti-Inflammatory Agents / therapeutic use
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C-Peptide / blood
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Diabetes Mellitus, Type 1 / complications*
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Diabetes Mellitus, Type 1 / diagnostic imaging
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Diabetes Mellitus, Type 1 / pathology
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Female
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Glutamate Decarboxylase / immunology
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Glutamate Decarboxylase / metabolism
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Humans
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Hydronephrosis / complications
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Hydronephrosis / pathology
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Middle Aged
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Retroperitoneal Fibrosis / complications*
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Retroperitoneal Fibrosis / diagnostic imaging
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Retroperitoneal Fibrosis / pathology
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Retroperitoneal Space / diagnostic imaging
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Retroperitoneal Space / pathology
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Steroids / therapeutic use
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Tomography, X-Ray Computed
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Ureter / pathology
Substances
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Anti-Inflammatory Agents
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C-Peptide
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Steroids
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Glutamate Decarboxylase
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glutamate decarboxylase 2