Acute renal failure due to visceral leishmaniasis by Leishmania infantum successfully treated with a single high dose of liposomal amphotericin B

J Travel Med. 2008 Sep-Oct;15(5):358-60. doi: 10.1111/j.1708-8305.2008.00220.x.

Abstract

We report a visceral leishmaniasis case in an immunocompetent immigrant with acute renal failure. Parasites were demonstrated in bone marrow, peripheral blood, and kidney samples. A collapsing focal segmental glomerulosclerosis was documented, which was successfully treated with a single infusion of 10 mg/kg liposomal amphotericin B.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / drug therapy*
  • Acute Kidney Injury / microbiology*
  • Adult
  • Amphotericin B / administration & dosage*
  • Angola
  • Animals
  • Antiprotozoal Agents / administration & dosage*
  • Dose-Response Relationship, Drug
  • Glomerulonephritis / drug therapy
  • Glomerulonephritis / microbiology
  • Humans
  • Italy
  • Leishmania infantum / isolation & purification
  • Leishmaniasis, Visceral / complications
  • Leishmaniasis, Visceral / diagnosis*
  • Leishmaniasis, Visceral / drug therapy*
  • Male
  • Travel*
  • Treatment Outcome

Substances

  • Antiprotozoal Agents
  • liposomal amphotericin B
  • Amphotericin B