Vasodilatation effect of farnesylacetones, active constituents of Sargassum siliquastrum, on the basilar and carotid arteries of rabbits

Byong-Gon Park; Seong-Chun Kwon; Gab-Man Park; Jungyeob Ham; Woon-Seob Shin; Seokjoon Lee

doi:10.1016/j.bmcl.2008.10.103

Vasodilatation effect of farnesylacetones, active constituents of Sargassum siliquastrum, on the basilar and carotid arteries of rabbits

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6324-6. doi: 10.1016/j.bmcl.2008.10.103. Epub 2008 Oct 26.

Authors

Byong-Gon Park¹, Seong-Chun Kwon, Gab-Man Park, Jungyeob Ham, Woon-Seob Shin, Seokjoon Lee

Affiliation

¹ Department of Physiology, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea.

PMID: 19006667
DOI: 10.1016/j.bmcl.2008.10.103

Abstract

Two farnesylacetones, 311 and 312, major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with farnesylacetones 311 and 312 may selectively accelerate cerebral blood flow through dilatation of the basilar artery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Basilar Artery / drug effects*
Blood Flow Velocity / drug effects
Cardiovascular Diseases / drug therapy
Carotid Arteries / drug effects*
Cerebrovascular Circulation / drug effects
Chemistry, Pharmaceutical / methods
Drug Design
Models, Chemical
Rabbits
Sargassum / metabolism*
Terpenes / chemistry*
Vasodilation / drug effects
Vasodilator Agents / chemical synthesis*
Vasodilator Agents / pharmacology*

Substances

Terpenes
Vasodilator Agents
farnesylacetone