A notch in the toll belt

Immunity. 2008 Nov 14;29(5):663-5. doi: 10.1016/j.immuni.2008.10.006.

Abstract

Two cell response pathways, Toll-like receptor (TLR) and Notch, conserved from Drosophila to mammals are well characterized for distinct roles in innate immunity and cell development, respectively. In this issue of Immunity, Hu et al. (2008) describe and characterize the direct cooperation of these two pathways.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cytokines / immunology*
  • Cytokines / metabolism
  • Humans
  • Immunity, Innate / genetics
  • Immunity, Innate / immunology
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / metabolism
  • Natural Killer T-Cells / immunology
  • Natural Killer T-Cells / metabolism
  • Receptors, Notch / immunology
  • Receptors, Notch / metabolism*
  • Signal Transduction*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • Toll-Like Receptors / immunology
  • Toll-Like Receptors / metabolism*

Substances

  • Cytokines
  • Receptors, Notch
  • Toll-Like Receptors