Chapter 11. The role of bone marrow-derived cells in tumor angiogenesis and metastatic progression

Marianna Papaspyridonos; David Lyden

doi:10.1016/S0076-6879(08)02811-5

Chapter 11. The role of bone marrow-derived cells in tumor angiogenesis and metastatic progression

Methods Enzymol. 2008:444:255-69. doi: 10.1016/S0076-6879(08)02811-5.

Authors

Marianna Papaspyridonos¹, David Lyden

Affiliation

¹ Department of Pediatrics and Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, USA.

PMID: 19007668
DOI: 10.1016/S0076-6879(08)02811-5

Abstract

Tumor angiogenesis is orchestrated by a complex set of secreted factors and collaboration between many different cell types. This chapter discusses the role of tumor-secreted angiogenic factors that are responsible for the recruitment of bone marrow-derived cells (BMDCs) at tumor sites and their role in tumor angiogenesis and progression.

MeSH terms

Animals
Bone Marrow Cells / cytology*
Cell Differentiation*
Cell Movement
Chemokine CXCL12 / metabolism
Disease Progression
Humans
Neoplasm Metastasis / pathology
Neoplasms / blood supply*
Neoplasms / metabolism
Neoplasms / pathology*
Neovascularization, Pathologic*
Receptors, CXCR4 / metabolism
Receptors, Vascular Endothelial Growth Factor / metabolism
Signal Transduction

Substances

Chemokine CXCL12
Receptors, CXCR4
Receptors, Vascular Endothelial Growth Factor