Localization of metastases from malignant pheochromocytoma in patients undergoing 131I-MIBG therapy with manually fused 123I-MIBG SPECT and CT images

J Nucl Med Technol. 2008 Dec;36(4):186-8. doi: 10.2967/jnmt.108.051656. Epub 2008 Nov 13.

Abstract

(131)I-metaiodobenzylguanidine (MIBG) has been used as a therapeutic agent for pheochromocytoma. Tumor localization and precise staging are essential for therapy with high-dose (131)I-MIBG. The sites and extent of (123)I-MIBG uptake are usually estimated to predict the effectiveness of therapy before administration. However, conventional scintigraphic images provide insufficient anatomic information. Therefore, we tried to manually superimpose (123)I-MIBG SPECT and CT images using free software.

Publication types

  • Evaluation Study
  • Validation Study

MeSH terms

  • 3-Iodobenzylguanidine / therapeutic use*
  • Adrenal Gland Neoplasms / diagnosis*
  • Feasibility Studies
  • Pheochromocytoma / diagnosis*
  • Pheochromocytoma / secondary*
  • Radiopharmaceuticals / therapeutic use
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*
  • Tomography, Emission-Computed, Single-Photon / methods*
  • Tomography, X-Ray Computed / methods*

Substances

  • Radiopharmaceuticals
  • 3-Iodobenzylguanidine