Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid

Shuho Tanimoto; Satoshi Sakai; Shuichi Matsumura; Daisuke Takahashi; Kazunobu Toshima

doi:10.1039/b811726h

Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid

Chem Commun (Camb). 2008 Nov 30:(44):5767-9. doi: 10.1039/b811726h. Epub 2008 Oct 2.

Authors

Shuho Tanimoto¹, Satoshi Sakai, Shuichi Matsumura, Daisuke Takahashi, Kazunobu Toshima

Affiliation

¹ Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.

PMID: 19009075
DOI: 10.1039/b811726h

Abstract

A designed fullerene-sugar hybrid effectively and selectively degraded the target protein, HIV-1 protease, which has high affinity for the fullerene moiety; degradation was achieved using long-wavelength UV or visible photo-irradiation, in the absence of any additives and under neutral conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrates / chemistry
Fullerenes / chemistry*
HIV Protease / metabolism*
Light
Photolysis*
Reactive Oxygen Species / metabolism
Ultraviolet Rays

Substances

Carbohydrates
Fullerenes
Reactive Oxygen Species
HIV Protease
p16 protease, Human immunodeficiency virus 1