Abstract
MICs of 10 oral antibiotics were determined for 105 Moraxella catarrhalis and 96 Haemophilus influenzae isolates from adults. A two- to fourfold increase in MICs of oral cephalosporins was seen in the presence of BRO-1 but not with TEM-1 or BRO-2. The MICs of cefixime for 90% of strains of H. influenzae (0.125 microgram/ml) and M. catarrhalis (0.25 microgram/ml) were 8- to 64-fold lower than those of other oral cephalosporins.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adult
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Amoxicillin / administration & dosage
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Amoxicillin / pharmacology
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Amoxicillin-Potassium Clavulanate Combination
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacology*
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Cefixime
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Cefotaxime / administration & dosage
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Cefotaxime / analogs & derivatives*
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Cefotaxime / pharmacology
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Cephalosporins / administration & dosage
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Cephalosporins / pharmacology
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Clavulanic Acids / administration & dosage
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Clavulanic Acids / pharmacology
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Dose-Response Relationship, Drug
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Drug Therapy, Combination / administration & dosage
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Drug Therapy, Combination / pharmacology
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Erythromycin / administration & dosage
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Erythromycin / pharmacology
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Haemophilus influenzae / drug effects*
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Humans
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Microbial Sensitivity Tests
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Moraxella catarrhalis / drug effects*
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Moraxella catarrhalis / enzymology
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Tetracycline / administration & dosage
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Tetracycline / pharmacology
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Clavulanic Acids
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Erythromycin
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Amoxicillin-Potassium Clavulanate Combination
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Amoxicillin
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Cefixime
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beta-Lactamases
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Tetracycline
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Cefotaxime