Abstract
Adjuvant perioperative liver infusion chemotherapy with fluorouracil, mitomycin and heparin caused mild but significant myelosuppression in the first two postoperative weeks. This was associated with a slightly increased bleeding tendency. Mortality was not increased. Future trials might combine chemotherapy with hematopoietic growth factors in order to minimize myelosuppression.
Publication types
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Clinical Trial
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Comparative Study
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / toxicity*
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / pathology
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Colonic Neoplasms / surgery
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Combined Modality Therapy
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Female
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Fluorouracil / administration & dosage*
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Fluorouracil / toxicity
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Follow-Up Studies
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Hemoglobins / drug effects
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Heparin / administration & dosage*
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Heparin / toxicity
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Humans
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Infusions, Intravenous
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Leukocyte Count / drug effects*
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Male
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Mitomycin
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Mitomycins / administration & dosage*
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Mitomycins / toxicity
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Platelet Count / drug effects*
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Portal Vein
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Random Allocation
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Rectal Neoplasms / drug therapy*
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Rectal Neoplasms / pathology
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Rectal Neoplasms / surgery
Substances
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Antineoplastic Agents
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Hemoglobins
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Mitomycins
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Mitomycin
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Heparin
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Fluorouracil