Abstract
Feronielloside (1), a new furanocoumarin glycoside, was isolated from roots of Feroniella lucida. The structure of 1 was elucidated by combined spectroscopic and chemical analysis. The absolute configuration of the chiral center in geranyl-derived side chain was confirmed by modified Mosher's method. Feronielloside inhibited acetylcholinesterase with IC(50) value of 24.7 mM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism*
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Cholinesterase Inhibitors* / chemistry
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Cholinesterase Inhibitors* / isolation & purification
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Cholinesterase Inhibitors* / pharmacology
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Coumarins* / chemistry
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Coumarins* / isolation & purification
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Coumarins* / pharmacology
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Furans* / chemistry
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Furans* / isolation & purification
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Furans* / pharmacology
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Glycosides* / chemistry
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Glycosides* / isolation & purification
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Glycosides* / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Rutaceae / chemistry*
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Thailand
Substances
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Cholinesterase Inhibitors
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Coumarins
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Furans
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Glycosides
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feronielloside
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Acetylcholinesterase