Abstract
A highly epidemic carbapenem-resistant clone of KPC-3-producing Klebsiella pneumoniae emerged in Israel in 2006, causing a nationwide outbreak. This clone was genetically related to outbreak strains from the United States isolated in 2000 but differed in KPC-carrying plasmids. The threat of the global spread of hyperepidemic, extensively drug-resistant bacterial strains should be recognized and confronted.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Carbapenems / pharmacology
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Disease Outbreaks*
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Drug Resistance, Bacterial / genetics*
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Israel / epidemiology
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Klebsiella Infections / epidemiology
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Klebsiella Infections / microbiology*
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / genetics*
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Microbial Sensitivity Tests
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Reverse Transcriptase Polymerase Chain Reaction
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United States / epidemiology
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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beta-Lactamases
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beta-lactamase KPC-3, Klebsiella pneumoniae