Sweet syndrome presenting as resistant conjunctivitis

Cornea. 2008 Dec;27(10):1189-90. doi: 10.1097/ICO.0b013e31817f8147.

Abstract

Purpose: We report a patient with chronic Sweet syndrome (SS) treated by anti-Tumor Necrosis Factor (TNF) therapy, who presented with a severe bilateral chemosis.

Methods: Case report.

Results: Conjunctival biopsy revealed an ocular localization of SS.

Conclusions: SS is a rare disorder that usually affects middle-age women. It is characterized by an acute febrile neutrophilic dermatosis. To our knowledge, this is the first documented case of an ocular localization in SS and the first report of a severe bilateral chemosis as ocular manifestation.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Aged
  • Antibodies, Monoclonal / adverse effects
  • Antibodies, Monoclonal / therapeutic use
  • Conjunctiva / blood supply
  • Conjunctiva / pathology
  • Conjunctival Diseases / etiology*
  • Conjunctival Diseases / pathology
  • Conjunctivitis / etiology*
  • Dose-Response Relationship, Drug
  • Edema / etiology*
  • Edema / pathology
  • Humans
  • Hyperemia / etiology
  • Infliximab
  • Male
  • Recurrence
  • Sweet Syndrome / complications*
  • Sweet Syndrome / drug therapy
  • Sweet Syndrome / pathology
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Antibodies, Monoclonal
  • Infliximab