Abstract
The effects of fullerenol C60(OH)24 (Frl) at doses of 25, 50, and 100mg/kg/week (for a time-span of 3 weeks) on heart and liver tissue after doxorubicin (Dox)-induced toxicity in rats with colorectal cancer were investigated. In the present study, we used an in vivo Wistar male rat model to explore whether Frl could protect against Dox-induced (1.5mg/kg/week for 3 weeks) chronic cardio- and hepato- toxicity and compared the effect with a well-known antioxidant, vitamin C (100mg/kg/week for 3 weeks). According to macroscopic, microscopic, hematological, biochemical, physiological, pharmacological, and pharmacokinetic results, we confirmed that, at all examined doses, Frl exhibits a protective influence on the heart and liver tissue against chronic toxicity induced by Dox.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abdominal Cavity / pathology
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Animals
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Body Weight / drug effects
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Cardiotoxins / toxicity
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Colorectal Neoplasms / blood
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Colorectal Neoplasms / enzymology
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Colorectal Neoplasms / pathology*
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Doxorubicin / toxicity*
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Electrocardiography
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Enzymes / blood
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Fullerenes / pharmacokinetics
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Fullerenes / pharmacology*
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Glutathione Disulfide / metabolism
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Heart / drug effects*
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Hemodynamics / drug effects
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Liver / drug effects*
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Liver / pathology
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Male
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Malondialdehyde / metabolism
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Myocardium / pathology
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Oxidation-Reduction / drug effects
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Oxidative Stress / drug effects
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Protective Agents / pharmacology*
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Rats
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Rats, Wistar
Substances
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Cardiotoxins
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Enzymes
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Fullerenes
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Protective Agents
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fullerenol
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Malondialdehyde
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Doxorubicin
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Glutathione Disulfide