Hereditary colorectal cancer syndromes and the role of the surgical oncologist

Peter A Learn; Morton S Kahlenberg

doi:10.1016/j.soc.2008.08.007

Hereditary colorectal cancer syndromes and the role of the surgical oncologist

Surg Oncol Clin N Am. 2009 Jan;18(1):121-44, ix. doi: 10.1016/j.soc.2008.08.007.

Authors

Peter A Learn¹, Morton S Kahlenberg

Affiliation

¹ Department of Surgery, University of Texas Health Science Center, San Antonio, Texas 78229, USA.

PMID: 19056045
DOI: 10.1016/j.soc.2008.08.007

Abstract

The expanding understanding of the genetic basis to hereditary colon cancer syndromes is dismantling previously conceived categorizations and shedding light on why those schemes often failed in past. This review highlights evolving concepts regarding the genetic diagnosis and clinical management of the more commonly inherited colorectal cancer syndromes, including a discussion of recently described familial syndromes. This review also addresses clinician responsibilities in recognition of familial syndromes and provision of counseling.

Publication types

Review

MeSH terms

Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis*
Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
Colorectal Neoplasms, Hereditary Nonpolyposis / surgery*
Genetic Counseling
Genetic Testing
Humans
Peutz-Jeghers Syndrome / diagnosis
Peutz-Jeghers Syndrome / surgery
Physician's Role*
Prognosis
Risk Assessment
Risk Factors